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  • Title: Beneficial effect of liposome-encapsulated muramyl tripeptide in experimental septicemia in a porcine model.
    Author: Izbicki JR, Raedler C, Anke A, Brunner P, Siebeck M, Leinisch E, Lüttiken R, Ruckdeschel G, Wilker DK, Schweiberer L.
    Journal: Infect Immun; 1991 Jan; 59(1):126-30. PubMed ID: 1987024.
    Abstract:
    In a porcine model of pneumococcal septicemia, animals were pretreated with 1 mg of liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (MTP-PE) or with liposomes alone. After 24 h each animal received an injection of either 10(9) or 10(10) pneumococcal serotype 6B cells. MTP-PE pretreatment resulted in less pronounced leukocytopenia, with a nadir of 6,700 (versus 4,100) leukocytes per mm3 after injection of 10(9) bacteria and a nadir of 4,400 (versus 3,800) leukocytes per mm3 after injection of 10(10) bacteria. At the same time bacterial clearance was substantially improved by MTP-PE pretreatment. Finally, pretreatment with MTP-PE dramatically reduced mortality; the average death rates for both series of animals used were 55% for liposome-pretreated animals and 3% for animals pretreated with MTP-PE-containing liposomes. These results in a preclinical model suggest that treatment with MTP-PE-containing liposomes might be beneficial in controlling septicemia in patients at risk.
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