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  • Title: Quantitative autoradiography reveals different angiotensin II receptor subtypes in selected rat brain nuclei.
    Author: Tsutsumi K, Saavedra JM.
    Journal: J Neurochem; 1991 Jan; 56(1):348-51. PubMed ID: 1987323.
    Abstract:
    Heterogeneity of rat brain angiotensin II receptors was revealed by quantitative autoradiography after incubation with 125I-Sar1-angiotensin II and displacement with the angiotensin II antagonists CGP 42112 A and DuP-753 and by receptor sensitivity to dithiothreitol. Receptors in areas involved in cardiovascular and fluid control--the subfornical organ, nucleus of the solitary tract, paraventricular nucleus, and area postrema--are displaced by DuP-753 with an IC50 of 1 x 10(-7) M, are sensitive to 5 mM dithiothreitol, and thus are angiotensin II type-1. Receptors in the inferior olive are displaced by CGP 42112 A (IC50, 1 x 10(-9) M) but not by DuP-753 in concentrations up to 10(-4) M, are insensitive to 5 mM dithiothreitol, and thus are angiotensin II type-2.
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