These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Symmetric macrocycles by a Prins dimerization and macrocyclization strategy.
    Author: Gesinski MR, Tadpetch K, Rychnovsky SD.
    Journal: Org Lett; 2009 Nov 19; 11(22):5342-5. PubMed ID: 19873984.
    Abstract:
    A tandem dimerization/macrocyclization reaction utilizing the Prins cyclization has been developed. This reaction develops molecular complexity through the formation of highly substituted dimeric tetrahydropyran macrocycles. Mild conditions utilizing rhenium(VII) catalysts were explored for aromatic substrates, while harsher Lewis acidic conditions were used for aliphatic substrates. Both aldehydes and acetals are shown to be viable substrates for this reaction.
    [Abstract] [Full Text] [Related] [New Search]