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  • Title: Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway.
    Author: Forestieri R, Merchant CE, de Voogd NJ, Matainaho T, Kieffer TJ, Andersen RJ.
    Journal: Org Lett; 2009 Nov 19; 11(22):5166-9. PubMed ID: 19873990.
    Abstract:
    The new sesterterpenoids alotaketals A (1) and B (2) have been isolated from extracts of the marine sponge Hamigera sp. collected in Papua New Guinea. Their chemical structures were elucidated by analysis of spectroscopic data. Alotaketals A and B have the unprecedented alotane carbon skeleton, and they activate the cAMP cell signaling pathway with EC(50)'s of 18 and 240 nM, respectively.
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