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  • Title: Polymorphism of glutathione S-transferases M1 and T1: susceptibility to solar keratoses in an Italian population.
    Author: Guarneri F, Asmundo A, Sapienza D, Gazzola A, Cannavò SP.
    Journal: Clin Exp Dermatol; 2010 Oct; 35(7):771-5. PubMed ID: 19874347.
    Abstract:
    BACKGROUND: Polymorphisms of glutathione S-transferases (GSTs) are linked to skin cancer, but data on their association with solar keratosis (SK) are few and conflicting. AIM: To verify the possible association between the development of SK and the 'null' GSTM1 and/or T1 genotype. METHODS: Analysis of the GSTM1 and T1 genotype of 33 subjects with ≥3 solar keratoses and of 150 controls, before and after stratification based on smoking habits, sun exposure and immunosuppression. RESULTS: The GST T1 null allele is significantly (P < 0.03) associated with increased prevalence of SK in our population. CONCLUSIONS: Our study, the first on a Mediterranean population, shows the existence of a correlation between SK and the GST T1 null genotype. This result points out significant differences between subjects of different ethnic and geographical origin and warrants further investigation on a larger population, and ethnically different populations.
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