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  • Title: Can a patient with neuroblastoma be diagnosed by a single urine sample collected randomly?
    Author: Nishi M, Miyake H, Takeda T, Takasugi N, Hanai J, Kawai T.
    Journal: Oncology; 1991; 48(1):31-3. PubMed ID: 1987496.
    Abstract:
    We have observed that a fairly large amount of vanillylmandelic acid and homovanillic acid in urine samples taken randomly from patients with a tumor of about 10 g was less than the cutoff values and overlapped with the respective ranges of normal infants. Consequently, with only a single random urine sample there is a risk of overlooking a patient, especially in cases where the tumor is small. However, according to theoretical calculation, several random urine samples may enable us to discriminate a patient from a normal infant and can replace the 24-hour urine accumulation for 3 days which is currently performed for final judgement in the mass screening of neuroblastoma.
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