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  • Title: [Effect of hypophyseal somatotropic, adrenocorticotropic and thyrotropic hormones on the protein component level in the aortal tissue of hypophysectomized rats].
    Author: Kovtuniak NA, Bordiakovskaia LG.
    Journal: Probl Endokrinol (Mosk); 1977; 23(2):99-103. PubMed ID: 198764.
    Abstract:
    The authors investigated changes in the content of collagen, noncollagen proteins, total glycoproteins, glycosaminoglycuronans in the aortic tissue of hypophysectomized rats with due regard for the regulatory effects of STH, ACTH and TTH. Replacement STH therapy led to an increase of oxyproline, hexuronic acids, hexoses in the aortic tissue of the hypophysectomized rats. With the action of ACTH under conditions of hypophysectomy there was a marked increase in the content of glyco- and mucoproteins and a reduction of glycosamines in the aortic tissue. The amount of glycosaminoglycuronans, collagen increased considerably under the effect of TTH in the aortic tissue of the hypophysectomized rats; as to the glyco- and mucoprotein content--in remained unchanged. ACTH, TTH and STH were administered from the 15th to the 21st day after hypophysectomy.
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