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  • Title: Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization.
    Author: Xerri L, Hassoun J, Planche J, Guigou V, Grob JJ, Parc P, Birnbaum D, deLapeyriere O.
    Journal: Am J Pathol; 1991 Jan; 138(1):9-15. PubMed ID: 1987771.
    Abstract:
    Biopsy samples from five acquired immune deficiency syndrome (AIDS)-Kaposi's sarcomas and one non-AIDS-associated Kaposi's sarcoma were assayed by in situ RNA hybridization onto paraformaldehyde-fixed, paraffin-embedded skin sections for the presence of two fibroblast growth factor gene transcripts, FGFB and FGF5. FGF5 gene expression was detected in the characteristic Kaposi's sarcoma spindle-shaped cells in the five samples from human immunodeficiency-positive (HIV+) patients. FGFB transcripts were detected in Kaposi's sarcoma cells as well as in epidermis of HIV- and HIV+ patients. These results complement the observations about growth factor gene expression done on Kaposi's sarcoma-derived cell lines, which thus appear to be representative of what happens in vivo. Furthermore, they demonstrate a contrasting expression pattern of FGF5 and FGFB genes, both involved in the growth factor pathogenic cascade leading to Kaposi's sarcoma.
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