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  • Title: Mesenchymal stem cells are functionally abnormal in patients with immune thrombocytopenic purpura.
    Author: Pérez-Simón JA, Tabera S, Sarasquete ME, Díez-Campelo M, Canchado J, Sánchez-Abarca LI, Blanco B, Alberca I, Herrero-Sánchez C, Cañizo C, San Miguel JF.
    Journal: Cytotherapy; 2009; 11(6):698-705. PubMed ID: 19878056.
    Abstract:
    BACKGROUND AIMS: Immune thrombocytopenic purpura (ITP) is a bleeding disorder characterized by an accelerated destruction of platelets as a result of the presence of autoreactive antibodies. Patients with ITP also display activated platelet-autoreactive T cells. Mesenchymal stem cells (MSC) inhibit both T- and B-cell activation and may have functional impairments in autoimmune disorders. METHODS: We analyzed the potential role of MSC in the pathogenesis of ITP. RESULTS: MSC from ITP showed an impaired proliferative capacity and a lower capability of inhibiting activated T-cell proliferation compared with healthy donors. While MSC from controls showed a decreased expression of p27 after stimulation with platelet-derived growth factor, this effect was not observed in MSC from patients. Furthermore, MSC from healthy donors down-regulated p16 upon exposure to platelet-released supernatant, while this effect was not observed for ITP. Interestingly, caspase 9 expression was higher in MSC from ITP. CONCLUSIONS: These abnormalities suggest a role of MSC malfunction in the physiopathology of the disease and may have therapeutic implications.
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