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  • Title: Preputial cellular and antibody responses of bulls vaccinated and/or challenged with Tritrichomonas foetus.
    Author: Cobo ER, Corbeil LB, Gershwin LJ, BonDurant RH.
    Journal: Vaccine; 2009 Dec 11; 28(2):361-70. PubMed ID: 19879225.
    Abstract:
    Systemic and genital immune responses in bulls were determined after infection with Tritrichomonas foetus and systemic vaccination with whole cell antigens. Vaccinated bulls resisted infection, developed IgG1 and IgG2 antibodies against T. foetus in preputial secretions and serum, and had increased MHC II(+) and CD205(+) cells (probably dendritic cells), CD3(+) and CD8(+) T cells, and B cells including IgG1 and IgA plasma cells in the prepuce. Non-vaccinated bulls challenged with T. foetus were persistently infected and had no detectable antibodies to T. foetus in either preputial secretions or serum for 6 weeks post challenge. We conclude that genital and serum IgG antibodies to T. foetus accounts for resistance of vaccinated bulls to T. foetus infection and that the lack of an antibody response in infected bulls accounts for persistent infection.
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