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  • Title: Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells.
    Author: Moumtzi SS, Roberts ML, Joyce T, Evangelidou M, Probert L, Frillingos S, Fotsis T, Pintzas A.
    Journal: Cancer Invest; 2010 Jul; 28(6):563-87. PubMed ID: 19883200.
    Abstract:
    We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle genes like c-fos, cyclin E, cdk2, cell-cell contact, and signaling like integrin a6, MEK5, and free radical signaling genes, like proline oxidase. Therefore, Ras-mediated signaling is a fine regulated process both positively and negatively influencing cell cycle, senescence, and apoptosis pathways. Novel early RAS-target genes could be potentially exploited in cancer diagnostics and therapeutics.
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