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  • Title: Amurensiosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis.
    Author: Kuroda M, Kubo S, Uchida S, Sakagami H, Mimaki Y.
    Journal: Steroids; 2010 Jan; 75(1):83-94. PubMed ID: 19883671.
    Abstract:
    Five new pregnane tetraglycosides, amurensiosides A-E (1-5), two new pregnane hexaglycosides, amurensiosides F (6) and I (9), two new 18-norpregnane hexaglycosides, amurensiosides G (7) and H (8), and two new pregnane octaglycosides, amurensiosides J (10) and K (11), were isolated from the MeOH extract of the roots of Adonis amurensis. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 human oral squamous cell carcinoma cells.
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