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  • Title: Efficiently mining time-delayed gene expression patterns.
    Author: Wang G, Yin L, Zhao Y, Mao K.
    Journal: IEEE Trans Syst Man Cybern B Cybern; 2010 Apr; 40(2):400-11. PubMed ID: 19884096.
    Abstract:
    Unlike pattern-based biclustering methods that focus on grouping objects in the same subset of dimensions, in this paper, we propose a novel model of coherent clustering for time-series gene expression data, i.e., time-delayed cluster (td-cluster). Under this model, objects can be coherent in different subsets of dimensions if these objects follow a certain time-delayed relationship. Such a cluster can discover the cycle time of gene expression, which is essential in revealing gene regulatory networks. This paper is the first attempt to mine time-delayed gene expression patterns from microarray data. A novel algorithm is also presented and implemented to mine all significant td-clusters. Our experimental results show following two results: 1) the td-cluster algorithm can detect a significant amount of clusters that were missed by previous models, and these clusters are potentially of high biological significance and 2) the td-cluster model and algorithm can easily be extended to 3-D gene x sample x time data sets to identify 3-D td-clusters.
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