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  • Title: Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus.
    Author: Lu A, Wang L, Zhang X.
    Journal: J Trop Pediatr; 2010 Aug; 56(4):242-6. PubMed ID: 19887538.
    Abstract:
    OBJECTIVE: To study the association of haplotypes of IL-8 -251T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV). METHODS: This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and 108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele's frequencies of SNPs were analyzed with case-control study, linkage of two loci and haplotypes composed by the two loci were also studied. RESULTS: (i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01). CONCLUSION: These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.
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