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  • Title: [Cycloartane triterpenoid of Cimicifuga foetida].
    Author: Dan C, Liang J, Zhou Y, Ding L.
    Journal: Zhongguo Zhong Yao Za Zhi; 2009 Aug; 34(15):1930-4. PubMed ID: 19894537.
    Abstract:
    OBJECTIVE: To study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity. METHOD: The compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition activity was then studied. RESULT: Thirteen cycloartane triterpenoids were isolated from the rhizomes of C. foetida and were characterized as 25-O-acetyl-cimigenol (1), cimigenol (2), cimicidanol (3), 26-deoxyactein (4), asiaticoside A (5), 23-epi-26-deoxyactein (6), actein (7), 12beta-hydroxycimigenol (8), cimiside E (9), (23R, 24S) 25-O-acetyl-cimigenol-3-O-beta-D-xylopyranoside (10), (23R, 24S) cimigenol-3-O-beta-D-xylopyranoside (11), cimicifugoside H-1 (12) and cimicifugoside H-2 (13). CONCLUSION: Compound 5 was isolated from this genus for the first time, compound 7 was isolated firstly from the plant and compound 2, 7, 10 and 11 exhibit osteoclast inhibition activity.
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