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  • Title: Synthesis and in vivo evaluation of 3-substituted gababutins.
    Author: Blakemore DC, Bryans JS, Carnell P, Chessum NE, Field MJ, Kinsella N, Kinsora JK, Osborne SA, Williams SC.
    Journal: Bioorg Med Chem Lett; 2010 Jan 01; 20(1):362-5. PubMed ID: 19897364.
    Abstract:
    A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.
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