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  • Title: [Experiences on the effectivity of prostaglandin F2alpha during labor after insufficient effect of oxytocin].
    Author: Hengst P, Halle H, Lau HU.
    Journal: Zentralbl Gynakol; 1977; 99(12):743-7. PubMed ID: 19901.
    Abstract:
    A report is given about the efficacy of prostaglandin F2alpha for induction of labour after inefficient application of oxytocininfusion. In all cases induction of labour was indicated or labour should be supported. 80 of the 104 women with weak labour finally delivered on vaginal way. Only 9 of 24 caesarean sections were performed by reason of weak labour in spite of application of prostaglandin F2alpha. There was no influence on the state of the newborns, this was the result of postnatal judgment by Apgar-score. Prostaglandin F-2 alpha was applied intrapartum in 104 women who (1) had indications for induction of labor (32 of them had premature rupture of the amniotic sac) and (2) had already received ineffective infusions of oxytocin. 80 women (77%) had vaginal deliveries; 24 had to have caesarean sections. Of these 24, however, only 9 were without strong obstetric indications for caesarean section (such as fetal heartbeat, fetal acidity, or intrapartum fever). 75 of the subjects were primiparae; the age range was 16-43. The prostaglandin was in a solution of 10-15 mcg/ml; the infusion rate was 5-22.5 mcg/minute. The mean time from infusion to birth was 180 minutes; mean time from 5-cm cervical dilation to birth was 114 minutes (cervical dilation was 2-3 cm at the beginning of prostaglandin application). No harmful effect on the state of the newborn was observed, as Apgar pH scores were similar to those of children born after spontaneous labor.
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