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  • Title: Mechanisms of granulocytopoiesis-stimulating activity of immobilized granulocytic colony-stimulating factor in cytostatic myelosuppression.
    Author: Dygai AM, Vereshchagin EI, Zhdanov VV, Zyuz'kov GN, Ermakova NN, Madonov PG, Miroshnichenko LA, Minakova MY, Simanina EV, Stavrova LA, Udut EV, Firsova TV, Khrichkova TY.
    Journal: Bull Exp Biol Med; 2009 Jul; 148(1):49-53. PubMed ID: 19902095.
    Abstract:
    The hemostimulatory effects of granulocytic CSF, immobilized on polyethyleneglycol using radiation synthesis nanotechnology, were studied on the model of cyclophosphamide-induced myelosuppression. Immobilization of granulocytic CSF led to stimulation of granulomonocytopoiesis by increasing functional activity of granulomonocytic precursors and secretion of humoral factors by elements of hemopoiesis-inducing microenvironment, and due to more intensive formation of hemopoietic islets. The granulocytopoiesis-stimulating effect of immobilized granulocytic CSF was comparable to the effect of standard nonconjugated granulocytic CSF. Specific activity of immobilized granulocytic CSF in oral treatment was demonstrated.
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