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  • Title: Chiral phosphoric acid-catalyzed desymmetrization of meso-aziridines with functionalized mercaptans.
    Author: Larson SE, Baso JC, Li G, Antilla JC.
    Journal: Org Lett; 2009 Nov 19; 11(22):5186-9. PubMed ID: 19905027.
    Abstract:
    Conditions for the phosphoric acid-catalyzed highly enantioselective ring-opening of meso-aziridines with a series of functionalized aromatic thiol nucleophiles are described. The procedure utilizes commercially available aromatic thiols, a series of meso-aziridines, and a catalytic amount of VAPOL phosphoric acid to explore the substrate scope of this highly enantioselective reaction.
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