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  • Title: Full automation of (68)Ga labelling of DOTA-peptides including cation exchange prepurification.
    Author: Ocak M, Antretter M, Knopp R, Kunkel F, Petrik M, Bergisadi N, Decristoforo C.
    Journal: Appl Radiat Isot; 2010 Feb; 68(2):297-302. PubMed ID: 19906533.
    Abstract:
    Here we describe a fully automated approach for the synthesis of (68)Ga-labelled DOTA-peptides based on pre-concentration and purification of the generator eluate by using a cation exchange-cartridge and its comparison with fully automated direct labelling applying fractionated elution. Pre-concentration of the eluate on a cation exchange cartridge both using a resin-based and a disposable cation-exchange cartridge efficiently removed (68)Ge as well as major metal contaminations with Fe and Zn. This resulted in a high labelling efficiency of DOTA-peptides at high specific activity (SA) with short synthesis times.
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