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  • Title: Hepatocyte transplantation into the lung for treatment of acute hepatic failure in the rat.
    Author: Then P, Sandbichler P, Erhart R, Dietze O, Klima G, Vogel W, Margreiter R.
    Journal: Transplant Proc; 1991 Feb; 23(1 Pt 1):892-3. PubMed ID: 1990717.
    Abstract:
    The lung was investigated as a matrix for transplanted hepatocytes in the rat model. Surgically induced fulminant hepatic failure was successfully treated by injection of 5 to 7 x 10(7) isolated hepatocytes into the pulmonary parenchyma in 86% of the animals. No animal, however, survived injection of hepatocytes into the jugular vein. It was found that liver failure is a prerequisite for the intrapulmonary survival of hepatocytes. After regeneration of the native liver, the majority of hepatocytes are cleared away within 6 months.
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