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  • Title: Effect of granulocytic colony-stimulating factor on cytostatic-suppressed granulocytopoiesis under conditions of exhausted catecholamine depot.
    Author: Dygai AM, Skurikhin EG, Pershina OV, Simanina EV, Minakova MY, Ermakova NN, Firsova TV, Khmelevskay ES.
    Journal: Bull Exp Biol Med; 2009 May; 147(5):609-12. PubMed ID: 19907751.
    Abstract:
    Exhaustion of catecholamine depot in the CNS before modeling of cytostatic myelosuppression potentiates the stimulatory effect of granulocytic CSF on regeneration of the granulocytic hemopoiesis stem. The increase in granulocyte count in the blood system under these conditions is caused by recovery of the structural and functional organization of the hemopoietic tissue (at the expense of reduction of the suppressive effect of catecholamines on the formation of granulocytic hemopoietic islets) and simultaneous stimulation of division and maturation of granulomonocytic precursors.
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