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  • Title: D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man.
    Author: Van Veldhoven PP, Brees C, Mannaerts GP.
    Journal: Biochim Biophys Acta; 1991 Jan 23; 1073(1):203-8. PubMed ID: 1991137.
    Abstract:
    By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.
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