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  • Title: Ellagic acid derivatives from Syzygium cumini stem bark: investigation of their antiplasmodial activity.
    Author: Simões-Pires CA, Vargas S, Marston A, Ioset JR, Paulo MQ, Matheeussen A, Maes L.
    Journal: Nat Prod Commun; 2009 Oct; 4(10):1371-6. PubMed ID: 19911574.
    Abstract:
    Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-alpha-L-2"-acetylrhamnopyranoside, 3-O-methylellagic acid 3'-O-alpha-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3'-O-beta-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of beta-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit beta-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds.
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