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  • Title: GD3-7-aldehyde is an apoptosis inducer and interacts with adenine nucleotide translocase.
    Author: Brenner C, Kniep B, Maillier E, Martel C, Franke C, Röber N, Bachmann M, Rieber EP, Sandhoff R.
    Journal: Biochem Biophys Res Commun; 2010 Jan 01; 391(1):248-53. PubMed ID: 19912988.
    Abstract:
    We prepared GD3-7-aldehyde (GD3-7) and determined its apoptotic potential. GD3-7 proved to be more efficient to induce pro-apoptotic mitochondrial alterations than GD3 when tested on mouse liver mitochondria. GD3-7-induced mitochondrial swelling and depolarization was blocked by cyclosporin A (CsA) supporting a critical role of the permeability transition pore complex (PTPC) during GD3-7-mediated apoptosis. In contrast to GD3, GD3-7 was able to induce channel formation in proteoliposomes containing adenine nucleotide translocase (ANT). This suggests that ANT is the molecular target of GD3-7. Using a specific antiserum, GD3-7 was detected in the lipid extract of the myeloid tumor cell line HL-60 after apoptosis induction, but not in living cells. Therefore, GD3-7 might be a novel mediator of PTPC-dependent apoptosis in cancer cells.
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