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  • Title: The response of hypoxic cells in SCCVII murine tumors to treatment with cisplatin and x rays.
    Author: Yan RD, Durand RE.
    Journal: Int J Radiat Oncol Biol Phys; 1991 Feb; 20(2):271-4. PubMed ID: 1991687.
    Abstract:
    Possible mechanisms of enhancement of radiation effects by cisplatin, including radiosensitization of hypoxic cells, drug-induced tumor reoxygenation, and inhibition of repair of sublethal radiation damage, were examined in the murine SCCVII model. Combination radiation/drug treatments were most effective when drug exposure preceded irradiation of animals breathing a reduced oxygen atmosphere, indicating that the primary interaction between the modalities was a cisplatin-induced increase in the oxygenation status of the acutely hypoxic cells in those tumors. Delivering cisplatin prior to or immediately after the first of two 5 Gy fractions was more effective than combinations with a single x-ray exposure, suggesting that proper sequences of the combined modalities may augment natural reoxygenation processes.
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