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  • Title: [Incidence of taste disorder associated with cancer patients undergoing chemotherapy on an ambulatory basis].
    Author: Sugawara S, Takimoto N, Iida A, Mori K, Sugiura M, Yamamura K, Adachi M.
    Journal: Gan To Kagaku Ryoho; 2009 Nov; 36(11):1871-6. PubMed ID: 19920390.
    Abstract:
    Taste disorders are a common complaint among cancer patients undergoing chemotherapy on an ambulatory basis. We conducted a survey on the incidence of such disorders among 74 patients, and 45.95% (34 of 74 patients) developed taste disorders. When stratified by medication into a regimen including 5-FU and one including taxanes, taste disorders were found in 59.0% (23 of 39 patients) of the former and 60.0% (9 of 15) of the latter. The survey also included the effects of taste disorders on patients appetites. Both regimens led to reduced appetite in a number of these patients (39.1% and 44.4%, respectively). Among patients on the 5-FU-containing regimen, the FOLFOX/FOLFIRI therapy was found to be responsible for loss of appetite. Regarding change in tastes, many patients stated that the medication dulled their taste sensation except for bitterness; their capacity to sense intensity of taste remained unchanged. It was found that acute taste disorders develop frequently among patients on a high dosage of 5-FU or a taxane-containing regimen.
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