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  • Title: Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.
    Author: Broek D, Bartlett R, Crawford K, Nurse P.
    Journal: Nature; 1991 Jan 31; 349(6308):388-93. PubMed ID: 1992340.
    Abstract:
    Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
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