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  • Title: Rivaroxaban, the first oral, direct factor Xa inhibitor.
    Author: Fassiadis N.
    Journal: Expert Opin Pharmacother; 2009 Dec; 10(18):2945-6. PubMed ID: 19925048.
    Abstract:
    Venous thromboembolism (VTE) is a major cause of death in hospitalized patients. In particular, patients undergoing elective major lower-limb orthopaedic surgery are at high risk of developing post-operative VTE. Rivaroxaban, a new oral anticoagulant, has been shown to be more effective than enoxaparin in reducing total and symptomatic VTE with similar major and non-major bleeding rates in patients undergoing elective total hip or total knee replacement.
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