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  • Title: Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m.
    Author: de Barros AL, Cardoso VN, Mota Ld, Alves RJ.
    Journal: Bioorg Med Chem Lett; 2010 Jan 01; 20(1):315-7. PubMed ID: 19926278.
    Abstract:
    Three carbohydrate derivatives, MAG(3)-Gl, MAG(3)-Ga, MAG(3)-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them, (99m)Tc-MAG(3)-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of (99m)Tc-MAG(3)-Ga to assess hepatic function can be considered.
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