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  • Title: Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.
    Author: Santos MM, Faria N, Iley J, Coles SJ, Hursthouse MB, Martins ML, Moreira R.
    Journal: Bioorg Med Chem Lett; 2010 Jan 01; 20(1):193-5. PubMed ID: 19926280.
    Abstract:
    We report here a simple entry into naphtho[2,3-d]isoxazole-4,9-dione system containing a EWG in position 3 using the readily available 2,3-dichloro-1,4-naphthoquinone and nitromethyl derivatives in the presence of base. Antifungal activity of synthesised naphthoquinones was evaluated against ATCC and PYCC reference strains of Candida. The results suggest that the naphtho[2,3-d]isoxazole-4,9-dione scaffold has the potential to be developed into novel and safe therapeutic antifungal agents.
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