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Title: Penetrating keratoplasty for unilateral corneal disease: outcomes from a tertiary care hospital in Australia.
Author: Jhanji V, Moorthy S, Constantinou M, Beltz J, Vajpayee RB.
Journal: Eye Contact Lens; 2010 Jan; 36(1):6-9. PubMed ID: 19927002.
Abstract:
PURPOSE: To assess the visual outcome after unilateral penetrating keratoplasty (PKP) in a heterogenous group of patients with unilateral corneal disease. METHODS: A retrospective analysis of hospital records of patients who had undergone PKP at the Royal Victorian Eye and Ear Hospital, Melbourne, Australia, over a 10-year period, was performed. All cases with a history of corneal transplantation surgery in one eye and a best-corrected visual acuity (BCVA) more than or equal to 0.5 in the fellow eye with no corneal pathologic condition were included. Outcome measures included BCVA at 2 years, and overall graft survival. RESULTS: Of the 498 grafts performed during the study period, 30 eyes (6%) met the inclusion criteria. The most common indications for PKP in the study group were bullous keratopathy (40%) and keratoconus (34%). The mean postoperative BCVA at 2 years (0.31 +/- 0.25; range, 0.033-1) was less than the mean BCVA of the fellow eye (0.77 +/- 0.20; range, 0.5-1) (P<0.00). Although there was a significant difference between the preoperative and postoperative BCVA (P<0.00), only 22% of patients could attain BCVA of more than or equal to 0.5. The major complications encountered were graft rejection (40%) and secondary graft failure (20%). CONCLUSIONS: Unilateral PKP is most commonly performed to treat bullous keratopathy and keratoconus in Australia and may be associated with suboptimal visual outcome as compared to the normal fellow eye.

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