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  • Title: Baroreflex-induced vasoconstriction in active skeletal muscle of conscious dogs.
    Author: O'Leary DS, Rowell LB, Scher AM.
    Journal: Am J Physiol; 1991 Jan; 260(1 Pt 2):H37-41. PubMed ID: 1992809.
    Abstract:
    We investigated the magnitude of baroreflex-mediated vasoconstriction in the hindlimbs of six conscious dogs at rest and during four levels of treadmill exercise ranging in intensity from mild (2 mph, 0% grade) to heavy (6 mph, 10% grade). Dogs were instrumented with vascular occluders on both common carotid arteries, an electromagnetic flow probe and vascular occluder on the terminal aorta, and a catheter in a branch of the femoral artery; aortic baroreceptors were intact. The responses to a 2-min carotid occlusion were observed at rest and after 3-5 min of exercise at each work rate. The increases in mean arterial pressure during carotid occlusion were similar at rest and at each level of exercise (26 +/- 4 to 35 +/- 3 mmHg; no significant difference). At rest, carotid occlusion caused only a small but significant decrease in terminal aortic vascular conductance (TAC) (-0.89 +/- 0.21 ml.min-1.mmHg-1, P less than 0.05). During mild exercise, baseline terminal aortic blood flow (TAQ) and TAC increased, and the reduction in TAC during carotid occlusion exceeded that observed at rest (-1.85 +/- 0.42 ml.min-1.mmHg-1, P less than 0.05). As exercise intensity increased, the magnitude of the reduction in TAC during carotid occlusion increased linearly with the baseline TAQ. At the highest work rate, approximately 59% of the increase in mean arterial pressure during carotid occlusion was due to the large decrease in TAC (-6.35 +/- 0.50 ml.min-1.mmHg-1). We conclude that the vasoconstriction of active skeletal muscle during the pressor response to bilateral carotid occlusion increased with exercise intensity.(ABSTRACT TRUNCATED AT 250 WORDS)
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