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  • Title: Synthesis of the macrocyclic core of iriomoteolide 3a.
    Author: Reddy CR, Dharmapuri G, Rao NN.
    Journal: Org Lett; 2009 Dec 17; 11(24):5730-3. PubMed ID: 19928780.
    Abstract:
    The asymmetric synthesis of the fully functionalized macrocyclic core of iriomoteolide 3a, a cytotoxic 15-membered macrolide, is disclosed. The key steps involve Sharpless asymmetric dihydroxylation, Sharpless asymmetric epoxidation, olefin cross-metathesis, Yamaguchi esterification, and a ring-closing metathesis reaction for macrocyclization.
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