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  • Title: ent-kaurane and ent-pimarane diterpenoids from Siegesbeckia pubescens.
    Author: Wang R, Chen WH, Shi YP.
    Journal: J Nat Prod; 2010 Jan; 73(1):17-21. PubMed ID: 19928884.
    Abstract:
    Phytochemical investigation of the above-ground parts of Siegesbeckia pubescens yielded 25 diterpenoids, including five new ent-pimarane diterpenoids (1-3, 11, and 12) and four new ent-kaurane diterpenoids (13-16). The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Single-crystal X-ray diffraction analysis confirmed the structures of 8, 13, and 14. Seven of these diterpenoids were evaluated for cytotoxic activity against HSC-T6, HeLa, and B16 cell lines. Compounds 11 and 14 exhibited moderate cytotoxicity.
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