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  • Title: A rare case of primary systemic amyloidosis of the neck with massive cervical lymph node involvement: a case report and review of the literature.
    Author: Seccia V, Dallan I, Cervetti G, Lenzi R, Marchetti M, Casani AP, Muscatello L.
    Journal: Leuk Res; 2010 Apr; 34(4):e100-3. PubMed ID: 19931179.
    Abstract:
    Amyloidosis is a term applied to a diverse group of disorders that share the deposition of amyloid protein in various extracellular tissues. Systemic amyloidosis may involve almost any organ system in the body including regions in the head and neck; however, neck lymph node involvement is rare, with only five previous cases reported. We present the case of a primary systemic AL amyloidosis with hepatic, cervical, retroperitoneal, axillary and inguinal lymphnode localizations, unresponsive to medical therapy and treated with a surgical approach followed by autologous bone marrow transplantation. We review the pertinent literature with exclusive attention to the otorhinolaryngologic aspect.
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