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  • Title: Hydrodynamic focusing of conducting fluids for conductivity-based biosensors.
    Author: Nasir M, Ateya DA, Burk D, Golden JP, Ligler FS.
    Journal: Biosens Bioelectron; 2010 Feb 15; 25(6):1363-9. PubMed ID: 19932019.
    Abstract:
    Hydrodynamic focusing of a conducting fluid by a non-conducting fluid to form a constricted current path between two sensing electrodes is implemented in order to enhance the sensitivity of a 4-electrode conductance-based biosensor. The sensor has a simple two-inlet T-junction design and performs four-point conductivity measurements to detect particles immobilized between the sensing electrode pair. Computational simulations conducted in conjunction with experimental flow studies using confocal microscopy show that a flat profile for the focused layer is dependent on the Reynolds number for the chosen flow parameters. The results also indicate that a flat focused layer is desirable for both increased sensitivity as well as surface-binding efficiency. Proof of concept for conductance measurements in a hydrodynamically focused conducting fluid was demonstrated with entrapped magnetic beads.
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