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  • Title: Microbial production of 2,3-butanediol by a mutagenized strain of Serratia marcescens H30.
    Author: Zhang L, Yang Y, Sun J, Shen Y, Wei D, Zhu J, Chu J.
    Journal: Bioresour Technol; 2010 Mar; 101(6):1961-7. PubMed ID: 19932023.
    Abstract:
    The production of 2,3-butanediol (2,3-BD) by Serratia marcescens H30 from sucrose was studied. Medium composition for 2,3-BD production by S. marcescens H30 was optimized in shake flask fermentations using Plackett-Burman design (PB) and response surface methodology (RSM). Results indicated that yeast extract and sodium acetate had significant effects on the 2,3-BD production. And their optimal concentrations were determined by RSM. The optimal medium was used to perform fermentation experiments by S. marcescens H30 in a 3.7l bioreactor. Several feeding strategies including interim feeding, exponential feeding and constant residual sucrose concentration feeding were compared for improving 2,3-BD production. Ultimately, a suitable control strategy which combined the respiratory quotient (RQ) control with the constant residual sucrose concentration fed-batch was developed. Using this strategy, the maximum 2,3-BD concentration of 139.92 g/l with the diol (AC+BD) productivity of 3.49 g/lh and the yield of 94.67% was obtained.
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