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  • Title: The T box mechanism: tRNA as a regulatory molecule.
    Author: Green NJ, Grundy FJ, Henkin TM.
    Journal: FEBS Lett; 2010 Jan 21; 584(2):318-24. PubMed ID: 19932103.
    Abstract:
    The T box mechanism is widely used in Gram-positive bacteria to regulate expression of aminoacyl-tRNA synthetase genes and genes involved in amino acid biosynthesis and uptake. Binding of a specific uncharged tRNA to a riboswitch element in the nascent transcript causes a structural change in the transcript that promotes expression of the downstream coding sequence. In most cases, this occurs by stabilization of an antiterminator element that competes with formation of a terminator helix. Specific tRNA recognition by the nascent transcript results in increased expression of genes important for tRNA aminoacylation in response to decreased pools of charged tRNA.
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