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  • Title: Preferential involvement of 11q23-24 and 11p15 in breast cancer.
    Author: Ferti-Passantonopoulou A, Panani AD, Raptis S.
    Journal: Cancer Genet Cytogenet; 1991 Feb; 51(2):183-8. PubMed ID: 1993303.
    Abstract:
    Thirty cases of breast cancer were cytogenetically studied by G-banding using direct tumor preparations. Among them 20 cases exhibited abnormalities of the long and/or short arm of chromosome 11. Thus, 11q was involved in 16 cases and 11p in ten cases. There was consistent involvement of bands 11q23-24 (15 cases) and 11p15 (9 cases), where the cellular oncogenes ets and H-ras 1, respectively, are located. These findings suggest that involvement of bands 11q23-24 and 11p15 may be specific in a group of breast cancers, leading to the activation of cellular oncogenes or loss of cancer suppressor genes.
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