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  • Title: Modafinil effects on cognitive function in HIV+ patients treated for fatigue: a placebo controlled study.
    Author: McElhiney M, Rabkin J, Van Gorp W, Rabkin R.
    Journal: J Clin Exp Neuropsychol; 2010 Jun; 32(5):474-80. PubMed ID: 19937504.
    Abstract:
    Both mild cognitive impairment and fatigue are common among people with HIV/AIDS. This study examined the efficacy of modafinil for HIV+ patients who sought treatment for fatigue in a placebo-controlled double-blind 4-week trial. A battery of standard neuropsychological tests was administered at study entry and Week 4, and change in performance was compared for 59 patients receiving modafinil versus 44 patients receiving placebo. A significant effect on fatigue was observed. In addition, cognitive performance, as measured by a global change score, improved more in the modafinil than in the placebo group although the effect was not specific to any cognitive domain.
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