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  • Title: Chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds.
    Author: Jia X, Yang D, Wang W, Luo F, Cheng J.
    Journal: J Org Chem; 2009 Dec 18; 74(24):9470-4. PubMed ID: 19938811.
    Abstract:
    A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds has been developed. Notably, the reaction employs K(3)[Fe(CN)(6)] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.
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