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  • Title: Phosphatases as targets for cancer treatment.
    Author: Lazo JS, Wipf P.
    Journal: Curr Opin Investig Drugs; 2009 Dec; 10(12):1297-304. PubMed ID: 19943201.
    Abstract:
    Although protein kinases are the molecular targets for an increasing number of anticancer agents, there is a notable absence of drugs targeting protein phosphatases, the biochemical counterpart of the protein kinases. This absence is particularly striking because many cancer-relevant pathways are also controlled by protein phosphatases, which can function abnormally in human tumors. Several research groups are searching for drug-like inhibitors of phosphatase-based cancer targets. This review examines several protein phosphatases for which investigational anticancer agents have been identified and are being investigated.
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