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  • Title: The effect of ecdysteroids on the microfilarial production of Brugia pahangi and the control of meiotic reinitiation in the oocytes of Dirofilaria immitis.
    Author: Barker GC, Mercer JG, Rees HH, Howells RE.
    Journal: Parasitol Res; 1991; 77(1):65-71. PubMed ID: 1994372.
    Abstract:
    The effects of the ecdysteroids ecdysone and 20-hydroxyecdysone on microfilarial release in Brugia pahangi and on meiotic reinitiation in the oocytes of Dirofilaria immitis were studied. Ecdysone was found to stimulate microfilarial release at 2 x 10(-6) M, but this effect was reduced at higher and lower concentrations. 20-Hydroxyecdysone was found to have no such effect. In D. immitis, ecdysone at 10(-5) M was also found to overcome the period of meiotic arrest that occurs during the pachytene stage of prophase 1. This effect was reduced when 10(-6) M ecdysone was used. These results help support the theory that the ecdysteroids play a hormonal role in filarial worms similar to that found in insects.
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