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  • Title: Renin-angiotensin gene polymorphisms and neurohormonal inhibition.
    Author: Pauly DF.
    Journal: Heart Fail Clin; 2010 Jan; 6(1):25-6. PubMed ID: 19945057.
    Abstract:
    Analyses of polymorphisms in the renin-angiotensin system may never completely predict responsiveness to pharmacotherapy that blocks angiotensin-converting enzyme or the angiotensin receptor type 1. However, the pharmacogenetic studies that have been conducted to date are intriguing, and they illustrate the potential benefit of designing larger genome-wide clinical studies. Such studies will continue to define the role of renin-angiotensin pharmacogenetics in patients with heart failure due to underlying cardiac dysfunction.
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