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  • Title: The molecular basis of the host response to lipopolysaccharide.
    Author: Bryant CE, Spring DR, Gangloff M, Gay NJ.
    Journal: Nat Rev Microbiol; 2010 Jan; 8(1):8-14. PubMed ID: 19946286.
    Abstract:
    Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.
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