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  • Title: Maternal flaxseed diet during lactation alters milk composition and programs the offspring body composition, lipid profile and sexual function.
    Author: Troina AA, Figueiredo MS, Moura EG, Boaventura GT, Soares LL, Cardozo LF, Oliveira E, Lisboa PC, Passos MA, Passos MC.
    Journal: Food Chem Toxicol; 2010 Feb; 48(2):697-703. PubMed ID: 19948200.
    Abstract:
    We evaluated the effects of maternal dietary flaxseed during lactation on milk composition, body composition and sexual function of the adult female offspring. The dams were fed a control casein diet (C) or flaxseed diet (F, 25%) throughout lactation. F mothers showed higher serum 17beta-estradiol (E2) and leptin at weaning. F mother's milk had lower total cholesterol (TC) and higher E2 and leptin. The offspring of F dams showed lower body mass (BM), body fat mass (BFM), visceral fat mass (VFM), TC and triglycerides (TG) and higher serum leptin and E2 at 21 days. F offspring showed delayed puberty onset. At 150 days, these offspring presented higher BFM, VFM, TC, TG, E2 and lower relative uterine weight and lower progesterone. In conclusion, flaxseed during lactation did affect the lipid profile, adipose tissue and sexual function in adulthood, probably due hyperestrogenism and hyperleptinemia at weaning.
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