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  • Title: Degradation of human cartilage by synovial fluid but not cytokines in vitro.
    Author: Hollander AP, Atkins RM, Eastwood DM, Dieppe PA, Elson CJ.
    Journal: Ann Rheum Dis; 1991 Jan; 50(1):57-8. PubMed ID: 1994871.
    Abstract:
    Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.
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