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  • Title: Selective stimulation of carboxylesterases metabolizing charged steroid esters by hydrocortisone.
    Author: Kaur S, Khanna P, Parmar SS, Ali B.
    Journal: Biochem Pharmacol; 1991 Feb 01; 41(3):476-8. PubMed ID: 1994908.
    Abstract:
    We observed a remarkable augmentation in the rate of hydrolytic breakdown of HCHS following exposure to corticosteroid therapy. This underscores the need for a careful reappraisal of its dosage in long term therapy. In such an event the uncharged ester may be the preferred drug of choice.
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