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  • Title: Effect of epidermal growth factor (EGF) on gluconeogenesis in isolated rat hepatocytes. Dependency on the red-ox state of the substrate.
    Author: Soler C, Poveda B, Pastor-Anglada M, Soley M.
    Journal: Biochim Biophys Acta; 1991 Jan 31; 1091(2):193-6. PubMed ID: 1995079.
    Abstract:
    It was found that EGF decreased both the basal- and the glucagon-stimulated gluconeogenesis from lactate alone or from a high lactate/pyruvate ratio and that it enhanced both the basal- and the glucagon-inhibited glucose synthesis from pyruvate alone or from a low lactate/pyruvate ratio. These findings demonstrate that the effect of both EGF and glucagon on glucose production by isolated hepatocytes depends on the red-ox state of the substrate.
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